生长抑制素能神经元在人胎丘脑网状核内的分布

本文用免疫细胞化学方法调查了生长抑素（ＳＯＭ）免疫反应神经元在人胎丘脑网状核内的分布。流产的胚胎３例,胎龄分别为１８周,２３周,３２周。意外死亡足月新生儿１例、在１８周胚胎的丘脑网状核内可见少数染色较浅的ＳＯＭ免疫反应阳性神经元,呈圆形。从１８周到３２周,ＳＯＭ免疫反应阳性细胞数明显增多,突起更丰富。在足月新生儿,ＳＯＭ阳性细胞数较３２周有所减少。结果表明,ＳＯＭ阳性神经元存在于人胎丘脑网状核内,并且有一定的发育过程。出现于人脑发育的早期阶段,可能在中枢神经系统的发育过程中起重要的作用。     

植物血细胞凝集素对小鼠脾脏淋巴细胞γ－谷氨酰基转肽酶活性的影响

本文就植物血细胞凝集素（ＰＨＡ）作用的不同时间对小鼠脾脏淋巴细胞γ－谷氨酰基转肽酶（γ－ＧＴ）活性的影响进行了观察。结果表明,脾脏淋巴细胞转化率随给予ＰＨＡ时间的延长而上升,对照组＜２４ｈ组＜４８ｈ组＜７２ｈ组;淋巴细胞γ－ＧＴ活性于２４ｈ明显强于对照组（Ｐ＜０．００１）,随着ＰＨＡ作用时间的延长其γ－ＧＴ活性逐渐下降,即４８ｈ组与对照组已无显著差异,而７２ｈ组却低于对照组（Ｐ＜０．００１）。可见ＰＨＡ在小鼠体内对γ－ＧＴ活性有很大影响。     

新疆呼图壁盐化草甸群落的DCA, CCA及DCCA分析

 本文应用DCA、CCA及DCCA排序技术对新疆呼图壁盐化草甸群落进行了分析。分析中选取了地下水位、粘土层出现深度、粘土层厚度、地下水pH值及地下水矿化度5个环境因子;同时为了分析空间格局对植被分异影响的大小,建立了样地空间坐标矩阵。结果表明：地下水位和地下水的pH值是引起植被分异的两个主要因素,空间格局对植被分异的影响大于环境因子对植被分异的影响。     

生长光强对亚热带自然林两种木本植物稳定碳同位素比、细胞间CO2浓度和水分利用效率的影响

生长于１００％、４０％和１６％自然光下的荷木和黧蒴幼苗叶片稳定碳同位素比（δ１３Ｃ,－‰）,细胞间ＣＯ２浓度（Ｃｉ）和水分利用效率（ＷＵＥ）有一定的差别。１６％和４０％弱光下,δ１３Ｃ的负值增加－０．５４Ｊ‰到－０．８９‰。Ｃｉ增大８．１－１３．２μｉＬ－１,ＷＵＥ则下降６－２４％。结果表明,叶片的水分和气体交换特性受生长光强的调节,叶片的δ１３Ｃ值可反映其生长过程中受光的强弱状况。     

Deletion between direct repeats in T7 DNA stimulated by double-strand breaks.

An in vitro system based on extracts of Escherichia coli infected with bacteriophage T7 was used to study genetic deletions between directly repeated sequences. The frequency of deletion was highest under conditions in which the DNA was actively replicating. Deletion frequency increased markedly with the length of the direct repeat both in vitro and in vivo. When a T7 gene was interrupted by 93 bp of nonsense sequence flanked by 20-bp direct repeats, the region between the repeats was deleted in about 1 out of every 1,600 genomes during each round of replication. Very similar values were found for deletion frequency in vivo and in vitro. The deletion frequency was essentially unaffected by a recA mutation in the host. When a double-strand break was placed between the repeats, repair of this strand break was often accompanied by the deletion of the DNA between the direct repeats, suggesting that break rejoining could contribute to deletion during in vitro DNA replication.     

聚焦色谱法测定肌型肌酸激酶亚型

报道了测定CK-MM亚型的聚焦色谱法,此法简单,快速,结果可靠,线性范围宽,最低检测限（8U／L）较正常参考值低,比国外报道的类似方法高6倍以上,分离度亦有改进.测定了20例健康人血清亚型分布,与文献报道结果相近.该法自动化程度高,已在急性心梗的诊断中实际应用.     

Chaetomella acutiseta produces chaetomellic acids A and B which are reversible inhibitors of farnesyl-protien transferase

Chaetomellic acids A and B, isolated from Chaetomella acutiseta, are specific inhibitors of farnesyl-protein transferase that do not inhibit geranylgeranyl transferase type 1 or squalene synthase. Chaetomellic acids A and B are reversible inhibitors, resemble farnesyl diphosphate and probably inhibit FPTase by substituting for farnesyl diphosphate. Chaetomellic acid production appears to be widespread within the genus Chaetomella. Correspondence to: R. B. Lingham     

脉冲电场对人红细胞膜结构影响的冷冻断裂研究

对外加脉冲电场处理的人红血球冷冻断裂和蚀刻的复型观察中发现在强电场(3KV/cm)作用下,细胞周围有颗粒状和纤维状结构。结合SDS电泳分析证明了它们是由于在电场作用下,红血球膜的带3蛋白和膜骨架蛋白(血影蛋白)脱出的结果。在强电场作用下,由于膜蛋白和膜骨架蛋白的脱出造成了对细胞膜的损伤,使细胞膜稳定性降低,细胞易变形和形成伪足。由于膜蛋白的脱出,多余的自由脂质进入细胞质内而形成泡状结构。外电场改变了蛋白-蛋白以及蛋白-脂分子间的作用可能是电穿孔的主要机理。本文还对当前公认的冷冻断裂中所观察到的膜中间颗粒的来源提出了疑问,并提出了它们还可能与冰晶有关。而冰晶的形成又与膜的亲水与疏水性有关。     

急性脑出血综合治疗的几个问题探讨：附死亡80例分析

通过对８０例急性脑出血死亡组分析,发现死于脑疝的占６２．５％,脑疝与一种或二种以上合并症同存者占７７．５％,显著高于存活组（Ｐ＜０．０１）．它们互为因果,加速死亡。因此,应重视早期或超早期采用简易定向锥颅脑内血肿碎吸术吸除血肿,同时注意维持生命体征稳定,加强脱水降颅压,预防、控制合并症等综合治疗。且要全面分析,相互兼顾,正确处置。这是帮助机体渡过调控障碍难关,挽救生命的有效治疗措施。